Browsing by Title
Now showing items 911-930 of 1801
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JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera.
(2019-12)The V617F mutation in the JH2 domain of Janus kinase 2 (JAK2) is an oncogenic driver in several myeloproliferative neoplasms (MPNs), including essential thrombocythemia, myelofibrosis, and polycythemia vera (PV). Other ... -
Job retention vocational rehabilitation for employed people with inflammatory arthritis (WORK-IA): a feasibility randomized controlled trial.
(2017-07)BACKGROUND: Inflammatory arthritis leads to work disability, absenteeism and presenteeism (i.e. at-work productivity loss) at high cost to individuals, employers and society. A trial of job retention vocational rehabilitation ... -
KAPT block: A new innovative precision block for operative outpatient hysteroscopy.
(RCOG World Congress 2016, 2016-06)To assess the effectiveness of a novel precision local anaesthetic block known as KAPT block in operative outpatient hysteroscopy especially in patients with pre-existing dysmenorrhea. -
Ketamine augmentation of electroconvulsive therapy to improve neuropsychological and clinical outcomes in depression (Ketamine-ECT): a multicentre, double-blind, randomised, parallel-group, superiority trial
(2017)Background The use of electroconvulsive therapy (ECT) is limited by concerns about its cognitive adverse effects. Preliminary evidence suggests that administering the glutamate antagonist ketamine with ECT might alleviate ... -
KI67 and DLX2 predict increased risk of metastasis formation in prostate cancer-a targeted molecular approach.
(2016-06)BACKGROUND: There remains a need to identify and validate biomarkers for predicting prostate cancer (CaP) outcomes using robust and routinely available pathology techniques to identify men at most risk of premature death ... -
Knowledge, attitude and barriers towards research in the national health service (NHS)
(2014-10)In the 21st century, healthcare professionals know a great deal about health, disease and medicine. However, much remains uncertain and continued investment in research aims to find better ways of managing patients, improving ... -
Lamotrigine for people with borderline personality disorder: A Randomised Control Trial
(2018)Background: No drug treatments are currently licensed for the treatment of borderline personality disorder (BPD). Despite this, people with this condition are frequently prescribed psychotropic medications and often with ... -
Language matters. Addressing the use of language in the care of people with diabetes: position statement of the English Advisory Group.
(2018-06)The language used by healthcare professionals can have a profound impact on how people living with diabetes, and those who care for them, experience their condition and feel about living with it day-to-day. At its best, ... -
Laparoscopic Roux en-Y Gastric Bypass Using a Modified Retrocolic-Supracolic Approach: Outcomes from 300 Patients.
(2016-03)BACKGROUND: Laparoscopic Roux en-Y gastric bypass (LRYGB) achieves sustained long-term weight loss and reduced mortality in morbidly obese patients. It is routinely performed using an ante- or retrocolic approach with the ... -
Laryngeal sensory testing in the assessment of patients with laryngopharyngeal reflux.
(2012-03)Laryngopharyngeal reflux is commonly encountered in the ENT out-patient setting. It leads to impaired sensory capacity of the laryngeal mucosa. The sensory integrity of the laryngopharynx can be evaluated through endoscopic ... -
Late discovery of a case with TAR syndrome who presented with an additional potential bleeding risk other than thrombocytopenia
(2013-04)The name of this syndrome based on an acronym describing the so called 'most obvious' clinical features: Absent Radii & Thrombocytopenia (TAR). There may however be more to TAR cases than what the name says. Development ... -
Learning about research: How can trainees in rehabilitation medicine become competent in appraising and conducting research?
(2010-12)This series of articles for rehabilitation in practice aims to cover a knowledge element of the rehabilitation medicine curriculum. Nevertheless they are intended to be of interest to a multidisciplinary audience. The ... -
Learning disability: experience of diagnosis
(2014)Studies have focused on the experience of diagnosis from the perspectives of parents of children with learning disabilities, but there has been limited methodologically rigorous investigation into the experience for the ... -
Legacy of COVID-19 - the opportunity to enhance surgical services for patients with colorectal disease.
(2020-08)After wide consultation with trainees, trainers, employers and other stakeholders, the new General Surgical Curriculum was approved earlier this year and will be implemented from 4 August 2021. It will be outcome based and ... -
Legg-Calvé-Perthes: interobserver and intraobserver reliability of the modified Herring lateral pillar classification.
(2013-03)The purpose of our study was to independently assess the reliability of the modified Herring lateral pillar classification. METHODS: Thirty-five standardized true anteroposterior radiographs of children in the fragmentation ... -
Lenalidomide before and after ASCT for transplant-eligible patients of all ages in the randomized, phase III, Myeloma XI trial.
(2020-06)The optimal way to use immunomodulatory drugs as components of induction and maintenance therapy for multiple myeloma is unresolved. We addressed this question in a large phase III randomized trial, Myeloma XI. Patients ... -
Leptin as a neuroprotective agent in glaucoma.
(2013-11)Glaucoma is a disease characterized by progressive optic nerve degeneration and is the leading cause of irreversible blindness worldwide. More than 60 million people globally are affected by glaucoma, of which 8 million ... -
Less is more: re-evaluating systematic reviews.
(2018-08)
