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Now showing items 1259-1278 of 1791
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Pro-protein subtilisin kexin-9 (PCSK9) inhibition in practice: lipid clinic experience in 2 contrasting UK centres
(2017-11)Prescribing criteria have been suggested for proprotein convertase subtilisin kexin-9 (PCSK-9) inhibitors but few studies exist of their real-world effectiveness. Methods: This study audited PCSK-9 inhibitor therapy in 105 ... -
Procarbazine-Free Escalated Beacopdac in Frontline Therapy of Advanced Hodgkin Lymphoma Reduces Red Cell Transfusion Requirements and May Shorten Time to Menstrual Period Recovery Compared to Escalated Beacopp and Appears to be As Efficacious
(2019-11)Since interim results from the EuroNet-PHL-C1 study1were published in 2013 showing that the gonadotoxic drug procarbazine in COPP can be safely replaced with dacarbazine (COPDac) it is increasingly common practice to modify ... -
Process and outcomes of the CAMHS ministerial taskforce-report and reflections on the ways in which clinicians can be involved in developing evidence-based policy.
(2015)Aims This session will describe the process by which the CAMHS Ministerial Taskforce was set up and the process of its work, with a recap of the outcomes/recommendations coming from that process. The presentation will also ... -
Profession-specific working in mental health: impacts for occupational therapists and service users
(2015)No abstract found -
The Prognosis in Palliative care Study II (PiPS2): study protocol for a multi-centre, prospective, observational, cohort study.
(2018-08)BACKGROUND: More accurate methods of prognostication are likely to lead to improvements in the quality of care of patients approaching the ends of their lives. The Prognosis in Palliative care Scales (PiPS) are prognostic ... -
Prognostic accuracy of emergency department triage tools for adults with suspected COVID-19: The PRIEST observational cohort study.
(2020-09)Objectives: The World Health Organisation (WHO) and National Institute for Health and Care Excellence (NICE) recommend various triage tools to assist decision-making for patients with suspected COVID-19. We aimed to estimate ... -
Prognostic accuracy of emergency department triage tools for children with suspected COVID-19: The PRIEST observational cohort study.
(2020-09)Objectives: Emergency department clinicians can use triage tools to predict adverse outcome and support management decisions for children presenting with suspected COVID-19. We aimed to estimate the accuracy of triage tools ... -
Prognostic significance of lymphatic invasion in lymph node positive breast carcinoma: findings from a large case series with long-term follow-up using immunohistochemical endothelial marker.
(2014-12)The poor prognostic significance of lymphatic invasion (LI) in breast carcinoma (BC) as a whole and in lymph node (LN)-negative patients in particular has been recognized in several studies; however, its prognostic role ... -
Progress in risk prediction for people with chronic kidney disease.
(2014-11)PURPOSE OF REVIEW: Chronic kidney disease is common, but the associated risk of adverse outcomes is heterogeneous and methods for risk stratification are, therefore, required. We have reviewed recent progress in developing ... -
Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT).
(2019-12)PURPOSE: The STAKT study examined short-term exposure (4.5 days) to oral selective pan-AKT inhibitor capivasertib (AZD5363) to determine if this drug can reach its therapeutic target in sufficient concentration to significantly ... -
Proliferation and AKT Activity Biomarker Analyses after Capivasertib (AZD5363) Treatment of Patients with ER+ Invasive Breast Cancer (STAKT).
(Clinical Cancer Research https://clincancerres.aacrjournals.org/content/26/7/1574.long, 2020-04)Purpose: The STAKT study examined short-term exposure (4.5 days) to the oral selective pan-AKT inhibitor capivasertib (AZD5363) to determine if this drug can reach its therapeutic target in sufficient concentration to ... -
Prolonged interruption of chemotherapy in patients undergoing delayed debulking surgery for advanced high grade serous ovarian cancer is associated with a worse prognosis.
(2020-04)INTRODUCTION: The current standard of care for advanced high grade serous ovarian cancer (HGSC) comprises a combination of debulking surgery and platinum-based chemotherapy given in the neoadjuvant or adjuvant setting. In ... -
Prophylactic antibiotics for penetrating abdominal trauma: duration of use and antibiotic choice.
(2019-12)BACKGROUND: Penetrating abdominal trauma (PAT) is a common type of trauma leading to admission to hospital, which often progresses to septic complications. Antibiotics are commonly administered as prophylaxis prior to ... -
Prophylactic oral vitamin k in neonates
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Prospective Clinical Trial Comparing Trapezial Denervation With Trapeziectomy for the Surgical Treatment of Arthritis at the Base of the Thumb.
(2019-02)BACKGROUND: Trapeziectomy is considered to be the "gold standard" procedure for first carpometacarpal joint (first CMCJ) osteoarthritis. First CMCJ denervation offers the potential benefit of a shorter procedure with bone ... -
Prospective Early Clinical, Radiological, and Kinematic Pedobarographic Analysis Following Subtalar Arthroereises for Paediatric Pes Planovalgus.
(2019-12)Introduction Arthroereises implants mechanically block eversion and limit subtalar motion. They are used in children with pes planovalgus in order to correct the valgus deformity. In this study, we aimed to objectively ... -
A prospective longitudinal study of Pasireotide in Nelson's syndrome.
(2018-01)PURPOSE: Nelson's syndrome is a challenging condition that can develop following bilateral adrenalectomy for Cushing's disease, with high circulating ACTH levels, pigmentation and an invasive pituitary tumor. There is no ... -
Prospective observational study to evaluate NOTSS (Non-Technical Skills for Surgeons) for assessing trainees' non-technical performance in the operating theatre
(2011)BACKGROUND: Most surgical assessment has been aimed at technical proficiency. However, non-technical skills also affect patient safety and clinical effectiveness. The NOTSS (Non-Technical Skills for Surgeons) assessment ... -
Prospective study of one-stop diagnostic and see-and-treat outpatient hysteroscopy service at Royal Derby Hospital
(2014-04)Introduction Abnormal uterine bleeding is the most common problem that a woman is referred with to a gynaecology clinic. This study evaluates the important role of a one-stop diagnostic, see-and-treat outpatient hysteroscopy ... -
Prospective study of surgical delay for hip fractures: impact of an orthogeriatrician and increased trauma capacity
(2009)Most health services in the United Kingdom provide unacceptable in-hospital care for hip fracture patients. We describe the impact on surgical delay following the introduction of an orthogeriatrician and the addition of ...
