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Now showing items 761-780 of 1791
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Histopathological evidence for macrophage activation driving post-transfusion hyperhaemolysis syndrome.
(2019-04)Post-transfusion hyperhaemolysis syndrome (PTHS) is a rare life-threatening transfusion complication reported mainly in sickle cell patients. Its pathogenesis is poorly understood. Antibody-mediated haemolysis and bystander ... -
Histopathological subgroups in knee osteoarthritis
(2017-01)OBJECTIVE: Osteoarthritis (OA) is a heterogeneous, multi-tissue disease. We hypothesised that different histopathological features characterise different stages during knee OA progression, and that discrete subgroups can ... -
HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants.
(2014-10)Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine or mercaptopurine. Its development is unpredictable and almost always leads to drug withdrawal. We identified patients with ... -
Home-administered pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): study protocol for a randomised controlled trial.
(2016-01-27)Background: Knee replacement surgery reduces pain for many people with osteoarthritis (OA). However, surgical outcomes are partly dependent on patients' moods, and those with depression or anxiety have worse outcomes. ... -
Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomized controlled trial.
(2018-02)Objective: To determine the feasibility of conducting a trial of a pre-surgical psychological intervention on pain, function, and mood in people with knee osteoarthritis listed for total knee arthroplasty. Design: ... -
Hormone replacement therapy in pre-menopausal women undergoing bilateral salpingo-oophorectomy for benign disease: A review of practice.
(2017-01)Introduction The National Institute for Health and Care Excellence (NICE) guideline on the diagnosis and management of the menopause states that women who are likely to go through the menopause as a result of surgical ... -
Hospital management of suicidal behaviour and subsequent mortality: A prospective cohort study.
(2015)Background: Self-poisoning and self-injury are associated with a high risk of suicide or death from any cause but the effect of routine aspects of hospital management on mortality risk is unknown. Methods: We did a prospective ... -
Hospitalization in Parkinson's disease: a survey of UK neurologists, geriatricians and Parkinson's disease nurse specialists.
(2015-03)INTRODUCTION: Care for people with Parkinson's admitted to hospital is often suboptimal and services for these patients vary. We conducted a national survey to document current service provision in the UK and to explore ... -
How accurate are TheraMon® microsensors at measuring intraoral wear-time? Recorded vs. actual wear times in five volunteers
(2017)BACKGROUND: The TheraMon® microsensor is the most recent device developed to measure the wear-time of removable appliances. The accuracy has not been validated intraorally. OBJECTIVES: To determine 1) if the TheraMon® ... -
How can referrals of patients who are obese to the local exercise referral scheme be increased? A UK based primary care quality improvement study.
(2020-06)Background: Obesity is classified as a body mass index (BMI) >30kg/m 2 and contributes to poor health outcomes in the UK. In 2017-18, obesity resulted in 711,000 hospital admissions. The National Institute for Health and ... -
How clinical observation enhances recruitment and selection.
(2012-11)A survey of nurse managers in Derby Hospitals NHS Foundation Trust in 2010 found 51 practitioners working at an advanced clinical level, but there were variations in titles, pay bands, clinical skills and academic ... -
How cognitive behavioural therapy can help in the treatment of schizophrenia
(2017)The perceptions and treatment of schizophrenia have changed radically in recent years. Today, alongside antipsychotic medications, the National Institute for Health and Care Excellence recommends the use of cognitive ... -
How do patients perceive the British orthodontic society online information resource about orthognathic treatment? A qualitative study
(2017)OBJECTIVES: To explore the accessibility, usability and relevance of the British Orthodontic Society (BOS) online information resource (OIR), Your Jaw Surgery. DESIGN: Qualitative, cross-sectional study. SETTING: 5 UK ... -
How do specialist trainee doctors acquire skills to practice patient-centred care? A qualitative exploration.
(2018-10)OBJECTIVES: The importance of patient-centred care (PCC) has been increasingly recognised. However, there is limited work exploring what doctors actually understand by PCC, and how they perceive they acquire PCC skills in ... -
How does role transition affect the experience of trainee Advanced Clinical Practitioners: Qualitative evidence synthesis
(2018-02)BackgroundAdvanced Clinical Practitioners have been developed to address current and future gaps in the medical workforce. Insight into problems associated with Advanced Clinical Practitioner transition may help present ... -
How good are surgeons at identifying appendicitis? Results from a multi-centre cohort study.
(2015-03)BACKGROUND: Convincing arguments for either removing or leaving in-situ a macroscopically normal appendix have been made, but rely on surgeons' accurate intra-operative assessment of the appendix. This study aimed to ... -
How to use... an autism assessment tool.
(2013)Autism is a neurodevelopmental condition affecting three main areas: social communication, social interaction and restricted patterns of behaviour, interests and activities. The Diagnostic and Statistical Manual of Mental ...
