Browsing by Title
Now showing items 928-947 of 1802
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Lenalidomide before and after ASCT for transplant-eligible patients of all ages in the randomized, phase III, Myeloma XI trial.
(2020-06)The optimal way to use immunomodulatory drugs as components of induction and maintenance therapy for multiple myeloma is unresolved. We addressed this question in a large phase III randomized trial, Myeloma XI. Patients ... -
Leptin as a neuroprotective agent in glaucoma.
(2013-11)Glaucoma is a disease characterized by progressive optic nerve degeneration and is the leading cause of irreversible blindness worldwide. More than 60 million people globally are affected by glaucoma, of which 8 million ... -
Less is more: re-evaluating systematic reviews.
(2018-08) -
Lesson of the month 1: Prolonged QT syndrome due to donepezil: a reversible cause of falls?
(2019)Prolonged QT syndrome precipitates cardiac arrhythmias such as torsades de pointes (TdP) resulting in cardiogenic syncope or sudden death. We report a case of prolonged QT syndrome caused by donepezil which resulted in a ... -
Lethal End of Spectrum of Clots-Thrombotic Storm.
(2018-05-27)Thrombotic storm (TS) is a rare, acute, hypercoagulable state characterized by multiple thromboembolic events affecting at least two different areas of the vascular system/organs over a short period of time. Typical triggers ... -
Letter: Cost-effectiveness analyses in ART consumerism require transparency, simplicity and reproducibility
(2021-01)No abstract available. -
LeucoPatch system for the management of hard-to-heal diabetic foot ulcers in the UK, Denmark, and Sweden: an observer-masked, randomised controlled trial.
(2018-09)BACKGROUND: The LeucoPatch device uses bedside centrifugation without additional reagents to generate a disc comprising autologous leucocytes, platelets, and fibrin, which is applied to the surface of the wound. We aimed ... -
Lidocaine-prilocaine cream versus local infiltration anaesthesia in pain relief during repair of perineal trauma after vaginal delivery: a systematic review and meta-analysis.
(2018-08)BACKGROUND: Perineal trauma is a common problem that may affect women during vaginal delivery; this trauma can either spontaneous (tear) or intentional (episiotomy). When repair of perineal trauma is required, adequate ... -
Lifelong learning in obstetrics and gynaecology: how theory can influence clinical practice
(2011)Lifelong learning refers to the systematic acquisition, renewal, updating and completion of knowledge. It is synonymous with the term 'self-directed learning'. This is a new educational strategy meant to consolidate knowledge ... -
Limited capsular release and controlled manipulation under anaesthesia for the treatment of frozen shoulder.
(2016-01)Background In light of recent interest in the cost-effectiveness of the treatment options available for frozen shoulder, we aimed to determine the results of limited anterior capsular release and controlled manipulation ... -
LIMPRINT in Specialist Lymphedema Services in United Kingdom, France, Italy, and Turkey.
(2019-04)Background: There is no standardized international model for specialist lymphedema services, which covers the types of lymphedema treated and the treatments provided. The aim of this study was to provide a profile of ... -
LIMPRINT: Estimation of the Prevalence of Lymphoedema/Chronic Oedema in Acute Hospital in In-Patients.
(2019-04)Background: To estimate the prevalence of lymphedema/chronic edema (CO) and wounds in acute hospital inpatients in five different countries. Methods and Results: A point-prevalence study was carried out during working day ... -
LIMPRINT: The UK Experience-Subjective Control of Swelling in Patients Attending Specialist Lymphedema Services.
(2019-04)Background and Study Design: This study was undertaken as part of the UK LIMPRINT international study to determine the number of people with chronic edema (CO) and its impact on health services. Overall 7436 with CO were ... -
Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology
(2013)GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds ratios (ORs) ranging from 0.75-0.85. We tested eight GAB2 variants ... -
Listeria monocytogenes: a rare cause for an infected abdominal aortic aneurysm.
(2011-11)Infected aneurysms associated with Listeria monocytogenes are rare. We describe a case of an infrarenal abdominal aortic aneurysm infected by Listeria monocytogenes. The aneurysm was diagnosed using a contrast-enhanced ... -
A literature review: The role of plakoglobin as a biomarker to determine the invasive potential of ductal carcinoma in situ
(2018-01)DCIS is a heterogeneous disease exhibiting varying degrees of aggressiveness; approximately 40% of DCIS will progress into invasive cancer. Currently, no molecular marker is identified that can reliably predict the invasive ... -
Little evidence for community treatment orders - a battle fought with heavy weapons
(2016)This editorial discusses the pros and cons of community treatment orders (CTOs) from the perspective of community general adult psychiatry. There is little scientific evidence supporting the application of CTOs. Preconditions ... -
Living with uncertainty and hope: A qualitative study exploring parents' experiences of living with childhood multiple sclerosis.
(2017-06)Background There is growing recognition that multiple sclerosis is a possible, albeit uncommon, diagnosis in childhood. However, very little is known about the experiences of families living with childhood multiple sclerosis ... -
A loaded self-managed exercise programme for patellofemoral pain: a mixed methods feasibility study.
(2019-03)BACKGROUND: A novel loaded self-managed exercise programme that includes pain education and self-management strategies may result in better outcomes for people with patellofemoral pain (PFP). However, establishing program ... -
Locking hemodialysis catheters with Trimethoprim-Ethanol-Ca-EDTA to prevent bloodstream infections. A randomized, evaluator blinded clinical trial.
(2018-10)Background: Central line associated bloodstream infections(CLABSI) often result from intraluminal microbial colonization and are associated with morbidity, mortality, and substantial costs. The use of antimicrobial catheter ...
