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Now showing items 941-960 of 1801
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Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology
(2013)GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds ratios (ORs) ranging from 0.75-0.85. We tested eight GAB2 variants ... -
Listeria monocytogenes: a rare cause for an infected abdominal aortic aneurysm.
(2011-11)Infected aneurysms associated with Listeria monocytogenes are rare. We describe a case of an infrarenal abdominal aortic aneurysm infected by Listeria monocytogenes. The aneurysm was diagnosed using a contrast-enhanced ... -
A literature review: The role of plakoglobin as a biomarker to determine the invasive potential of ductal carcinoma in situ
(2018-01)DCIS is a heterogeneous disease exhibiting varying degrees of aggressiveness; approximately 40% of DCIS will progress into invasive cancer. Currently, no molecular marker is identified that can reliably predict the invasive ... -
Little evidence for community treatment orders - a battle fought with heavy weapons
(2016)This editorial discusses the pros and cons of community treatment orders (CTOs) from the perspective of community general adult psychiatry. There is little scientific evidence supporting the application of CTOs. Preconditions ... -
Living with uncertainty and hope: A qualitative study exploring parents' experiences of living with childhood multiple sclerosis.
(2017-06)Background There is growing recognition that multiple sclerosis is a possible, albeit uncommon, diagnosis in childhood. However, very little is known about the experiences of families living with childhood multiple sclerosis ... -
A loaded self-managed exercise programme for patellofemoral pain: a mixed methods feasibility study.
(2019-03)BACKGROUND: A novel loaded self-managed exercise programme that includes pain education and self-management strategies may result in better outcomes for people with patellofemoral pain (PFP). However, establishing program ... -
Locking hemodialysis catheters with Trimethoprim-Ethanol-Ca-EDTA to prevent bloodstream infections. A randomized, evaluator blinded clinical trial.
(2018-10)Background: Central line associated bloodstream infections(CLABSI) often result from intraluminal microbial colonization and are associated with morbidity, mortality, and substantial costs. The use of antimicrobial catheter ... -
Locoregional recurrence of breast cancer presenting as upper limb venous thromboembolism
(2017)Locoregional recurrence of breast cancer is a major concern for both patient and oncologist. Presentation as venous thromboembolism (VTE) carries risk of delayed diagnosis and has a poor prognosis. Here we describe, for ... -
Locoregional recurrence of breast cancer presenting as upper limb venous thromboembolism
(2017-08)Locoregional recurrence of breast cancer is a major concern for both patient and oncologist. Presentation as venous thromboembolism (VTE) carries risk of delayed diagnosis and has a poor prognosis. Here we describe, for ... -
The Long Term Outcome of MRSA Infection in Elective Orthopaedic Surgery a Longitudinal Population Study in a District Hospital
(2015)Discussion References This study looked at long term morbidity and mortality prospectively following MRSA infection over an 18 year period in patients undergoing elective surgery in a 600 bedded district ... -
Long Term Outcomes after Acute Kidney Injury: Lessons from the ARID Study.
(2015-09)The high incidence and poor short-term outcomes of acute kidney injury (AKI) have focused attention on this global healthcare issue. Concurrently, the long-term effects of AKI are increasingly appreciated, namely, increased ... -
Long Term Performance of an Uncemented, Proximally Hydroxyapatite Coated, Double Tapered, Titanium-Alloy Femoral Stem: Results From 1465 Hips at 10 years Minimum Follow-Up.
(2020-08)BACKGROUND: We assessed the survivorship of a proximally hydroxyapatite coated, double tapered, titanium-alloy femoral stem in a single center, at an average follow up of 12.5 years (10.1-15.8). The majority of stems were ... -
Long term survivorship following Scorpio Total Knee Replacement.
(2015-06)BACKGROUND: The Scorpio Total Knee Replacement (TKR) is one of the most commonly used prosthesis in the United Kingdom. Concerns arose at our institution that there was a high revision rate for this prosthesis. No study ... -
Long-term antidepressant treatment for negative symptoms in schizophrenia: The actions study
(2017)Background: The negative symptoms of schizophrenia represent defcien-cies in emotional responsiveness, motivation and socialization that tend to be persistent despite standard antipsychotic treatment. Two sub-domains of ... -
Long-Term Follow-Up of Complete Versus Lesion-Only Revascularization in
(2019-12)BACKGROUND: Randomized trials have shown that complete revascularization in patients with ST-segment elevation myocardial infarction (MI) with multivessel disease results in lower major adverse cardiovascular events ... -
Long-term outcomes after AKI-a major unmet clinical need.
(2019-01)In this issue of Kidney International, a comprehensive systematic review and meta-analysis provides an up-to-date picture of the long-term risks of death, chronic kidney disease (CKD), and end-stage kidney disease (ESKD) ... -
Long-Term Outcomes in Patients with Acute Kidney Injury.
(2020-02)The long-term sequelae of AKI have received increasing attention so that its associations with a number of adverse outcomes, including higher mortality and development of CKD, are now widely appreciated. These associations ... -
Long-term outcomes of biological mesh repair following extra levator abdominoperineal excision of the rectum: an observational study of 100 patients.
(2019-08)BACKGROUND: Current evidence suggests that pelvic floor reconstruction following extralevator abdominoperineal excision of rectum (ELAPER) may reduce the risk of perineal herniation of intra-abdominal contents. Options for ... -
Longitudinal Trends in Quality of Life and Physical Function in Frail Older Dialysis Patients: A Comparison of Assisted Peritoneal Dialysis and In-center Hemodialysis
(2019-01)BACKGROUND: In-center hemodialysis (HD) has been the standard treatment for older dialysis patients, but reports suggest an associated decline in physical and cognitive function. Cross-sectional data suggest that assisted ...
