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Potentially pathogenic circulating autoantibodies to cardiac troponin are present in hemodialysis patients.
(2016-11)
Introduction Repetitive dialysis-induced cardiac injury is associated with elevated troponin levels, inflammation, and longitudinal reduction in cardiac function. Pathogenic autoantibodies to cardiac troponins (cTnAAb) ...
An Investigation Into the Role of Osteocalcin in Human Arterial Smooth Muscle Cell Calcification.
(2020-06)
Osteocalcin (OCN) is a bone-derived protein that is detected within human calcified vascular tissue. Calcification is particularly prevalent in chronic kidney disease (CKD) patients but the role of OCN in calcification, ...
Tissue advanced glycation end product deposition after kidney transplantation.
(2013-10)
BACKGROUND: Tissue advanced glycation end products (AGEs) accumulate in chronic kidney disease (CKD) and are a measure of cumulative metabolic stress. Measurement of tissue AGEs by skin autofluorescence (SAF) correlates ...
Troponin T for the detection of dialysis-induced myocardial stunning in hemodialysis patients.
(2012-08)
BACKGROUND AND OBJECTIVES: Circulating troponin T levels are frequently elevated in patients undergoing long-term dialysis. The pathophysiology underlying these elevations is controversial. DESIGN, SETTING, PARTICIPANTS, ...
Creation of an arteriovenous fistula is associated with significant acute local and systemic changes in microvascular function.
(2013-08)
BACKGROUND: Native arteriovenous fistulae (AVF) are the vascular access of choice for haemodialysis. The consequences of AVF formation on microvascular function, locally or systemically, are unknown. METHODS: We recruited ...
Skin autofluorescence and the association with renal and cardiovascular risk factors in chronic kidney disease stage 3.
(2011-10)
BACKGROUND AND OBJECTIVES: Tissue advanced glycation end products (AGE) accumulation is a measure of cumulative metabolic stress. Assessment of tissue AGE by skin autofluorescence (SAF) correlates well with cardiovascular ...
Predicting and managing complications of renal replacement therapy in the critically ill.
(2012-10)
Renal replacement therapy (RRT) remains associated with a significant risk of serious complications, and critically ill patients requiring RRT continue to manifest particularly poor overall survival rates. These poor ...
Volume is not the only key to hypertension control in dialysis patients.
(2012-07)
There is a widely held belief that hypervolaemia due to excess intake or inadequate removal of salt and water is the principal cause of hypertension in dialysis patients. The risk of failing to consider additional ...
The impact of antihypertensive drug therapy on endotoxemia in elderly patients with chronic kidney disease.
(2011-11)
BACKGROUND AND OBJECTIVES: Endotoxin (ET) is recognized to cause adverse effects on cardiovascular (CV) structure. Circulatory translocation of gut bacterial ET is described in heart failure. Chronic kidney disease (CKD) ...
The pathophysiology of the chronic cardiorenal syndrome: a magnetic resonance imaging study
(2015-06)
OBJECTIVE: To study the association of renal function with renal perfusion and renal parenchymal structure (T1 relaxation) in patients with chronic heart failure (HF) METHODS: After IRB approval, 40 participants were ...