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Multimorbidity in people with chronic kidney disease: implications for outcomes and treatment.
(2016-08)
PURPOSE OF REVIEW: With ageing populations, the prevalence of multimorbidity is increasing. This review discusses recent developments in the understanding of multimorbidity in the context of chronic kidney disease (CKD). ...
Determinants of change in arterial stiffness over 5 years in early chronic kidney disease.
(2019-09)
BACKGROUND: Arterial stiffness (AS) is an established and potentially modifiable risk factor for cardiovascular disease associated with chronic kidney disease (CKD). There have been few studies to evaluate the progression ...
An updated overview of diabetic nephropathy: Diagnosis, prognosis, treatment goals and latest guidelines.
(2020-04)
Diabetic nephropathy (DN) is a major healthcare challenge. It occurs in up to 50% of those living with diabetes, is a major cause of end-stage kidney disease (ESKD) that requires treatment with dialysis or renal transplantation, ...
Chronic kidney disease: towards a risk-based approach.
(2016-12)
Chronic kidney disease (CKD) affects 8-16% of adults worldwide and is associated with multiple adverse outcomes. It includes a heterogeneous group of conditions with widely varied associated risks; risk stratification is ...
Tissue advanced glycation end product deposition after kidney transplantation.
(2013-10)
BACKGROUND: Tissue advanced glycation end products (AGEs) accumulate in chronic kidney disease (CKD) and are a measure of cumulative metabolic stress. Measurement of tissue AGEs by skin autofluorescence (SAF) correlates ...
Skin autofluorescence: an emerging biomarker in persons with kidney disease.
(2019-11)
PURPOSE OF REVIEW: Skin autofluorescence (SAF) is a measure of the accumulation of advanced glycation end-products (AGEs) proposed to act as a marker of 'cumulative metabolic stress'. This article discusses mechanisms of ...
The association of skin autofluorescence with cardiovascular events and all-cause mortality in persons with chronic kidney disease stage 3: A prospective cohort study.
(2020-07)
BACKGROUND: Tissue advanced glycation end product (AGE) accumulation has been proposed as a marker of cumulative metabolic stress that can be assessed noninvasively by measurement of skin autofluorescence (SAF). In persons ...
The authors reply
(2020-01)
We agree with Rosansky and Thamer1 that creatinine methodology is a critical component of glomerular filtration rate estimation. We can reconfirm that in our study, we used the same internationally standardized enzymatic ...
An unusual case of severe high anion gap metabolic acidosis
(2011-04)
We present a case of high anion gap metabolic acidosis with an unusual aetiology in a 75-year-old lady with hypoglycaemia, encephalopathy and relatively preserved renal function. Full toxicology and biochemical analysis ...