Search
Now showing items 1-10 of 27
6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE): 4-year disease-free survival results of a randomised phase 3 non-inferiority trial.
(2019-06)
BACKGROUND: Adjuvant trastuzumab significantly improves outcomes for patients with HER2-positive early breast cancer. The standard treatment duration is 12 months but shorter treatment could provide similar efficacy while ...
Improving primary care identification of familial breast cancer risk using proactive invitation and decision support.
(2020-06)
Family history of breast cancer is a key risk factor, accounting for up to 10% of cancers. We evaluated the proactive assessment of familial breast cancer (FBC) risk in primary care. Eligible women (30 to 60 years) were ...
Current trends in breast surgery.
(2012-12)
Breast surgery has evolved significantly over the last decade. This includes developments in pre-operative assessment of patients and surgical options offered to patients. Oncoplastic breast surgery has emerged as a new ...
Effect of second timed appointments for non-attenders of breast cancer screening in England: a randomised controlled trial.
(2017-05)
BACKGROUND: In England, participation in breast cancer screening has been decreasing in the past 10 years, approaching the national minimum standard of 70%. Interventions aimed at improving participation need to be ...
Menstrual cycle associated changes in hormone-related gene expression in oestrogen receptor positive breast cancer.
(2019-11)
The major changes in hormone levels that occur through the menstrual cycle have
been postulated to affect the expression of hormone-regulated and proliferation-associated genes (PAGs) in premenopausal ER+ breast cancer. ...
Occult breast carcinoma in breast reduction specimens in European women.
(2011-08)
Breast reduction is a common surgical procedure performed by plastic and oncoplastic breast surgeons. The authors report on the incidence and management of cancer and atypical hyperplasia in breast reduction specimens from ...
Individualising breast cancer treatment to improve survival and minimise complications in older women: a research programme including the PLACE RCT.
(2019-08)
BACKGROUND: Over 44,000 women are diagnosed with breast cancer annually in the UK. The research comprised three workstreams (WSs) focused on older women. MAXIMISING SURVIVAL: WS1 – to identify the role of older women’s and ...
Symmetrisation procedures in breast reconstruction patients constitute a rising workload in our DGH.
(2014-12)
INTRODUCTION: In breast cancer patients undergoing reconstructive surgery, achieving symmetry is of considerable importance. The aim of our study was to identify the proportion of breast cancer patients undergoing ...
Axillary treatment for patients with early breast cancer and lymph node metastasis: systematic review protocol.
(2013-01)
BACKGROUND: For patients with early breast cancer and lymph node metastasis, axillary treatment is widely recommended. This is either surgical removal of the axillary lymph nodes, or axillary radiotherapy. The rationale ...