Browsing Gynaecology by Issue Date
Now showing items 1-20 of 49
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Eag and HERG potassium channels as novel therapeutic targets in cancer.
(2010-12)Voltage gated potassium channels have been extensively studied in relation to cancer. In this review, we will focus on the role of two potassium channels, Ether à-go-go (Eag), Human ether à-go-go related gene (HERG), in ... -
Synovial sarcoma of the vulva: a case report.
(2011-03)INTRODUCTION: Contrary to its name, synovial sarcoma does not arise from the synovial membrane but from multipotent stem cells and can present in any part of the body. Very few cases of vulval synovial sarcoma have been ... -
Obstetric and neonatal outcomes for women with reversed and non-reversed type III female genital mutilation.
(2011-05)OBJECTIVE: To record and compare obstetric and neonatal complication rates in women with reversed and non-reversed type III female genital mutilation (FGM). METHODS: A retrospective observational study comparing cesarean ... -
Preoperative serum albumin is an independent prognostic predictor of survival in ovarian cancer.
(2011-07)Ovarian cancer is associated with high mortality due to asymptomatic nature of the disease and advance stage at presentation. In advanced stages, it is associated with cachexia and ascites leading to malnutrition. Nutritional ... -
The relationship of ethnicity, maternal height and shoe size, and method of delivery.
(2011-10)In a bid to determine the relationship of ethnicity, maternal height and shoe size as predictors of cephalopelvic disproportion, we conducted a prospective comparative study of primigravidas at term with singleton pregnancies, ... -
Pelvic mass associated with raised CA 125 for benign condition: a case report.
(2012-04)BACKGROUND: Raised CA 125 with associated pelvic mass is highly suggestive of ovarian malignancy, but there are various other benign conditions that can be associated with pelvic mass and a raised CA 125. CASE PRESENTATION: ... -
A case of caesarean scar ectopic pregnancy-successful treatment with intra-amniotic methotrexate followed by a systemic course of intramuscular methotrexate
(2013-12)Case: A 34-year-old woman, G5 P2 was seen at the Royal Derby Hospital in early pregnancy. Previous deliveries were by emergency caesarean section, the first at 30 weeks of gestation for a ruptured uterus and the second at ... -
Prospective study of one-stop diagnostic and see-and-treat outpatient hysteroscopy service at Royal Derby Hospital
(2014-04)Introduction Abnormal uterine bleeding is the most common problem that a woman is referred with to a gynaecology clinic. This study evaluates the important role of a one-stop diagnostic, see-and-treat outpatient hysteroscopy ... -
An audit of outpatient hysteroscopy in Royal Derby Hospital
(2014-04)Introduction Hysteroscopy offers an extension of the gynaecologists' armamentarium as it improves the diagnostic accuracy and permits better treatment of abnormal intra-uterine conditions. All gynaecological units should ... -
Female adipocyte androgen synthesis and the effects of insulin
(2014-06)The metabolic syndrome is a cluster of metabolic disorders characterized by insulin resistance and hyperinsulinaemia, and its presence can increase the risk of cardiovascular disease significantly. The metabolic syndrome ... -
Enigma of urethral pain syndrome: why are there so many ascribed etiologies and therapeutic approaches?
(2014-06)Urethral pain syndrome has had several sobriquets, which have led to much confusion over the existence of this pathological condition and the useful options in the care of the afflicted patient. Our aim was to explore the ... -
"I'm 100% for it! I'm a convert!": women's experiences of a yoga programme during treatment for gynaecological cancer; an interpretative phenomenological analysis.
(2015-02)To explore patients' experiences of taking part in a yoga intervention while undergoing treatment for gynaecological cancer. Sixteen women (age range 31-79 years; mean age 60) participated in focus groups based on a ... -
Acute herpes simplex encephalitis in pregnancy.
(2015-03) -
Risk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening.
(2015-06)PURPOSE: Cancer screening strategies have commonly adopted single-biomarker thresholds to identify abnormality. We investigated the impact of serial biomarker change interpreted through a risk algorithm on cancer detection ... -
Setting up of ambulatory hysteroscopy service.
(2015-10)There is an obvious trend towards developing ambulatory procedures in gynaecology with ambulatory hysteroscopy as its mainstay. In the recent years, the fast pace of modern technological advances in gynaecologic endoscopy, ... -
Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial.
(2016-03)BACKGROUND: Ovarian cancer has a poor prognosis, with just 40% of patients surviving 5 years. We designed this trial to establish the effect of early detection by screening on ovarian cancer mortality. METHODS: In this ... -
Patent foramen ovale as a cause of platypnea orthodeoxia syndrome presenting in pregnancy: A case report and review of the literature
(2016-06)Background At 8 weeks into her third IVF pregnancy, a 40-yearold doctor presented to the Royal Derby Hospital with dyspnoea. Her breathing had worsened since the drainage of 5 litres of ascites from ovarian hyperstimulation ... -
The impact of excision of benign nonendometriotic ovarian cysts on ovarian reserve: a systematic review.
(2016-08)BACKGROUND: Benign nonendometriotic ovarian cysts are very common and often require surgical excision. However, there has been a growing concern over the possible damaging effect of this surgery on ovarian reserve. OBJECTIVE: ... -
Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary
(2017)OBJECTIVE: The pathogenesis of polycystic ovary syndrome (PCOS), a common endocrine disease and metabolic disturbance, is still unknown. The aim of the study was to investigate whether patients with PCOS display increased ... -
Effect of antipsychotics on mitochondrial bioenergetics of rat ovarian theca cells
(2017)Background: Antipsychotics (APs) are widely prescribed drugs, which are well known to cause reproductive adverse effects through mechanisms yet to be determined. The purpose of this study was to investigate the effect of ...
