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Pain sensitivity in healthy volunteers and people with knee Osteoarthritis
Background: Osteoarthritis (OA) is the most common form of arthritis worldwide and a major cause of pain and disability, and yet underlying mechanisms of OA pain are not entirely understood. There is compelling evidence ...
Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis.
Summary: Objective: To systematically review the use of Quantitative sensory testing (QST) in pain characterisation (phenotyping) in Osteoarthritis (OA). Methods: Six bibliographic databases (Medline, Embase, Amed, Cinahl, ...
Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis.
Objective: Osteoarthritis (OA) is a major source of knee pain. Mechanisms of OA knee pain are incompletely understood but include synovial pathology. We aimed to identify molecular expression patterns in the synovium ...
Pain mechanisms in rheumatoid arthritis
Understanding of the causes and underlying mechanisms of pain in people with RA is rapidly changing. With the advent of more effective disease modifying drugs, joint inflammation is becoming a more treatable cause of pain, ...
A cross-sectional study of pain sensitivity, disease-activity assessment, mental health, and fibromyalgia status in rheumatoid arthritis.
INTRODUCTION: Pain remains the most important problem for people with rheumatoid arthritis (RA). Active inflammatory disease contributes to pain, but pain due to non-inflammatory mechanisms can confound the assessment ...
Interpretation of 28-Joint Disease Activity Score and its Components in the Assessment of Inflammatory and Non-Inflammatory Aspects of Rheumatoid Arthritis
Background: The 28-joint DAS with ESR (DAS28-ESR) is used as a measure of inflammatory disease activity in RA. However, pain and non-inflammatory mechanisms (e.g. central sensitisation) might confound the DAS28 by modulating ...
An unusual cause of sudden onset shoulder pain in a child
6-year-old previously well child presented to the emergency department with a history of sudden onset left shoulder pain.
The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis.
Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. Identification of the mechanisms driving inflammation could reveal new targets to relieve this prevalent pain state. Herein, a ...
Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data.
(McWilliams, D. F. et al. (2016) ‘Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data’, Arthritis Research & Therapy, 18, p. 295., 2016-12-13)
ACKGROUND: Rheumatoid arthritis (RA) disease activity is often measured using the 28-joint Disease Activity Score (DAS28). We aimed to identify and independently verify subgroups of people with RA that may be discordant ...
Trajectories of pain predict disabilities affecting daily living in arthritis.
PURPOSE: To examine the interplay between pain and disability in arthritis when adjusting for patient heterogeneity in pain progression. There is consistent evidence to suggest that people experience osteoarthritis ...