To assess whether anti-mullerian hormone varies between women of different race/ethnic backgrounds
Introduction: Anti-Mullerian hormone, secreted by the granulosa cells in the ovary, is used as an estimate of ovarian reserve and to predict the ovarian response to ovarian stimulation during assisted conception treatments. Differences in serum AMH levels amongst various ethnic groups have been reported in the literature. The results from literature have been conflicting and not uniform as regards the population and ethnic groups studied. Ovarian reserve remains an important predictor of the success of fertility treatments, ethnic differences in AMH may contribute to the differences in outcome of these treatments. Methods: Observational cross-sectional study of 1215 patients who had levels measured between April 2009 to September 2014 at Royal Derby Hospital over a period of 5 years. Serum Anti-Mullerian hormone levels were compared amongst women from three different ethnic groups. Results: A total of 1215 women studied, 874 were Caucasians, 178 were Asians, 23 were Afro Caribbean's, 4 from mixed back ground and 128 of them have not stated their ethnicity. The data shows that Caucasians had high levels of Anti-Mullerian hormone compared to Asian and African women at younger age (up to 30 yrs). Caucasian women showed highest decline in Anti-Mullerian hormone levels compared to Asian and African women between 30-44yrs. African women had lowest Anti-Mullerian hormone levels throughout their reproductive period compared to Caucasians and Asians. Discussion / Conclusion: As age advances AMH levels decrease, the degree of age related AMH decline vary depending on ethnicity, cause of subfertility and type of subfertility. Ethnicity should be considered while interpreting AMH results. Improving our understanding of racial differences in ovarian reserve and their underlying causes may be essential for reproductive planning, improved treatment outcomes.
- Maternity