Pathology
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Histopathological evidence for macrophage activation driving post-transfusion hyperhaemolysis syndrome.
(2019-04)Post-transfusion hyperhaemolysis syndrome (PTHS) is a rare life-threatening transfusion complication reported mainly in sickle cell patients. Its pathogenesis is poorly understood. Antibody-mediated haemolysis and bystander ... -
Identification of rare diseases by screening a population selected on the basis of routine pathology results-the PATHFINDER project: lysosomal acid lipase/cholesteryl ester storage disease substudy.
(2018-07)AIMS: Lysosomal acid lipase deficiency (LALD) is an autosomal recessive disorder of cholesterol ester storage associated with hepatic disease, cirrhosis and accelerated atherosclerosis. Its prevalence in the general ... -
Differential diagnosis for chronic hypokalaemia.
(2018-06)Doctors will often see patients with chronic hypokalaemia, frequently this is secondary to gastrointestinal losses, diuretics or renal disease. However, in this case report we review a rarer cause of chronic hypokalaemia-Gitelman ... -
Eltrombopag and Romiplostim: A snapshot from Derby Teaching Hospitals
(2018-04)Severe Idiopathic Thrombocytopenic Purpura (ITP) is a relatively common disorder with a small but definite associated mortality. For many years, first line therapy has consisted of steroid or Intravenous Immunoglobulin. A ... -
NHS Breast Screening multidisciplinary working group guidelines for the diagnosis and management of breast lesions of uncertain malignant potential on core biopsy (B3 lesions).
(2018-05)Needle core biopsy is considered the histological diagnostic method of choice for screen-detected breast lesions. Although the majority are definitively diagnosed as normal, benign, or malignant, approximately 7% are ... -
An update on trials of novel lipid-lowering drugs.
(2018-03)PURPOSE OF REVIEW: A number of novel trials have assessed the efficacy of new lipid-lowering therapies in cardiovascular disease (CVD). RECENT FINDINGS:Proprotein convertase subtilisin kexin-9 inhibitors reduce low-density ... -
An update on trials of novel lipid-lowering drugs
(2018-03)PURPOSE OF REVIEW: A number of novel trials have assessed the efficacy of new lipid-lowering therapies in cardiovascular disease (CVD). RECENT FINDINGS: Proprotein convertase subtilisin kexin-9 inhibitors reduce low-density ... -
Sweat Testing Since The Introduction Of Newborn Screening In West Midlands, UK
(2014)Background Cystic Fibrosis (CF) is an autosomal recessive condition caused by gene mutation which affects sodium and chloride transport across the membrane of secretory epithelial cells. New born screening for CF was ... -
Rare necrotic lesion in a pregnant woman.
(2018-03)A 34-year-old female community nurse in her first trimester of pregnancy presented with a 2-week history of a tender, swollen and hyperkeratotic lesion on her chest with no history of trauma. The lesion started as a red ... -
Cholesteryl ester storage disease: a rare and possibly treatable cause of premature vascular disease and cirrhosis
(2013-09)Cholesteryl ester storage disease (CESD) is an autosomal recessive lysosomal storage disorder caused by a variety of mutations of the LIPA gene. These cause reduced activity of lysosomal acid lipase, which results in ... -
Identification of rare diseases by screening a population selected on the basis of routine pathology results-the PATHFINDER project: lysosomal acid lipase/cholesteryl ester storage disease substudy
(2018-01)AIMSLysosomal acid lipase deficiency (LALD) is an autosomal recessive disorder of cholesterol ester storage associated with hepatic disease, cirrhosis and accelerated atherosclerosis. Its prevalence in the general population, ... -
Pro-protein subtilisin kexin-9 (PCSK9) inhibition in practice: lipid clinic experience in 2 contrasting UK centres
(2017-11)Prescribing criteria have been suggested for proprotein convertase subtilisin kexin-9 (PCSK-9) inhibitors but few studies exist of their real-world effectiveness. Methods: This study audited PCSK-9 inhibitor therapy in 105 ... -
IQC trending with unity software and evaluation of the bio-rad EQAS blood typing system
(2016-09)Derby Teaching Hospitals NHS Foundation Trust provides both acute hospital and community based health services, serving a population of over 600,000 people in and around Southern Derbyshire. The Royal Derby Hospital, which ... -
Understanding patterns of ordering common blood tests in patients admitted to hospital-an audit to evaluate number and frequency of common blood tests in admitted patients in a medium sized DGH
(2013-06)Blood tests play a very important part in the diagnosis and management of most diseases and pathology costs form significant proportion of the health service budget. The Independent Review of Pathology Services in the ... -
Late discovery of a case with TAR syndrome who presented with an additional potential bleeding risk other than thrombocytopenia
(2013-04)The name of this syndrome based on an acronym describing the so called 'most obvious' clinical features: Absent Radii & Thrombocytopenia (TAR). There may however be more to TAR cases than what the name says. Development ... -
Two case studies showing the importance of Coumarin tracing blood assays to investigate acquired coagulopathies in patients with selfharm behaviour
(2013-04)We have recent experience of two cases who presented with unexplained coagulopathies. Neither of them had a family or previous personal history of a bleeding tendency. They both denied the use of any medication. One case ...
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