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    Interpretation of 28-Joint Disease Activity Score and its Components in the Assessment of Inflammatory and Non-Inflammatory Aspects of Rheumatoid Arthritis

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    Abstract
    Background: The 28-joint DAS with ESR (DAS28-ESR) is used as a measure of inflammatory disease activity in RA. However, pain and non-inflammatory mechanisms (e.g. central sensitisation) might confound the DAS28 by modulating the visual analogue scale for general health (VAS-GH) and tender joint count (TJC). Several transformations have rearranged the DAS28 formula in an attempt to measure non-inflammatory pain contributions in RA. We aimed to compare different DAS28 components and these derived measures to assess their utility in the analysis of non-inflammatory factors and to inform interpretation of the DAS28 as an index of RA inflammatory disease activity.
    URI
    https://orda.derbyhospitals.nhs.uk/handle/123456789/1746
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    • Rheumatology [31]
    Date
    2016-04-28
    Author
    Wilson, Deborah
    Walsh, David A
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