ORDA - Online Research Data Archive 
    • Login
    View Item 
    •   ORDA Home
    • Sherwood Forest Hospitals NHS Foundation Trust
    • Urgent and Emergency Care
    • Acute Medicine
    • View Item
    •   ORDA Home
    • Sherwood Forest Hospitals NHS Foundation Trust
    • Urgent and Emergency Care
    • Acute Medicine
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Lethal End of Spectrum of Clots-Thrombotic Storm.

    Thumbnail
    Abstract
    Thrombotic storm (TS) is a rare, acute, hypercoagulable state characterized by multiple thromboembolic events affecting at least two different areas of the vascular system/organs over a short period of time. Typical triggers include inflammation, infections, minor trauma, surgery, pregnancy, and the puerperium. A single thrombotic event can set off a number of thromboembolic events, often including unusual locations like hepatic, portal, or renal veins, skin (purpura fulminans), adrenal glands, and cerebral sinus venous thrombosis. Usually, younger female patients are affected; in some patients, there is an association with an autoimmune disorder like lupus erythematosus, and they show evidence of antiphospholipid antibodies or other phenotypic expressions of anticoagulation disorders. The majority of patients have no previous history of thromboembolism. As the diagnosis of thrombotic storm relies solely on clinical symptoms with a lack of specific diagnostic tests, this can result in a delay of diagnosis. The treatment consists of uninterrupted lifelong anticoagulation. Sometimes immunomodulatory therapies have been used. The distinction between extensive thrombotic events like Heparin Induced Thrombosis (HIT), Thrombotic Thrombocytopenic Purpura (TTP), Antiphospholipids Syndrome (APS), and TS can sometimes be difficult, and the etiology of TS remains uncertain.
    URI
    https://orda.derbyhospitals.nhs.uk/handle/123456789/1775
    Collections
    • Acute Medicine [4]
    Date
    2018-05-27
    Author
    Fischer-Orr, Nicola
    Naser, Kamal
    Show full item record
    Fischer-Orr 2018 7272420.pdf (2.775Mb)

    copyright © 2017  Derby Teaching Hospitals NHS Foundation Trust
    Contact Us | Send Feedback
    Powered by KnowledgeArc
     

     

    Browse

    All of ORDACommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    Researcher Profiles

    Researchers

    My Account

    Login

    copyright © 2017  Derby Teaching Hospitals NHS Foundation Trust
    Contact Us | Send Feedback
    Powered by KnowledgeArc