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Chronic obstructive pulmonary disease: diagnosis and management: summary of updated NICE guidance.
(2019-07-29)This article summarises the most recent recommendations from the National Institute for Health and Care Excellence (NICE). The updated areas are mainly concerned with the management of stable COPD and include self management ... -
P671 Experiences of using vedolizumab in the treatment of inflammatory bowel disease in the East Midlands: a retrospective observational study.
(2019-03)Randomised controlled trials have demonstrated efficacy of vedolizumab in ulcerative colitis (UC) and Crohn’s disease (CD). Its use is increasing and data in the real-world setting is needed to inform future practice.A ... -
The UK Pleural Society.
(2019-04)With over 65 separate conditions affecting the pleura it is clear that pleural disease contributes hugely to the workload of respiratory physicians, who increasingly recognize pleural disease as a sub-specialty in its own ... -
Measure of activity performance of the hand (MAP-Hand) questionnaire: linguistic validation, cultural adaptation and psychometric testing in people with rheumatoid arthritis in the UK
(2018-07-31)BACKGROUND: Developed in the Norway, the Measure of Activity Performance of the Hand (MAP-Hand) assesses 18 activities performed using the hands. It was developed for people with rheumatoid arthritis (RA) using patient ... -
Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis.
(2019-04)OBJECTIVE: Osteoarthritis (OA) is a major source of knee pain. Mechanisms of OA knee pain are incompletely understood but include synovial pathology. We aimed to identify molecular expression patterns in the synovium ... -
The impact of anxiety on chronic musculoskeletal pain and the role of astrocyte activation.
(2019-03)Anxiety and depression are associated with increased pain responses in chronic pain states. The extent to which anxiety drives chronic pain, or vice versa, remains an important question that has implications for analgesic ... -
The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis.
(2019-03-18)Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. Identification of the mechanisms driving inflammation could reveal new targets to relieve this prevalent pain state. Herein, a ... -
Trajectories of pain predict disabilities affecting daily living in arthritis.
(2019-04-07)PURPOSE: To examine the interplay between pain and disability in arthritis when adjusting for patient heterogeneity in pain progression. There is consistent evidence to suggest that people experience osteoarthritis ... -
Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data.
(McWilliams, D. F. et al. (2016) ‘Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data’, Arthritis Research & Therapy, 18, p. 295., 2016-12-13)ACKGROUND: Rheumatoid arthritis (RA) disease activity is often measured using the 28-joint Disease Activity Score (DAS28). We aimed to identify and independently verify subgroups of people with RA that may be discordant ... -
Surgical lung biopsy for interstitial lung disease: when considered necessary, should these be done in larger and experienced centres only?
(2019-02-21)Surgical lung biopsy for ILD: higher volume centres may offer lower mortality, but data are only suggestive – we need more research, including into lower risk alternatives to conventional biopsy, to reduce risk for patients ... -
Acute Transient Stress Induced Adrenal Hypertrophy and Adrenal Medullary Hyperactivity.
(2015)Objectives: Adrenal gland hypertrophy can be related to acute stress with abnormal adrenal function tests. It may not always need treatment. Material and methods: An acute presentation of adrenal gland hypertrophy following ... -
Energy and nutrient intakes of Sri Lankan patients with type 2 diabetes mellitus: a cross-sectional survey.
(2015-08-12)Background: Sri Lanka has a high prevalence of type 2 diabetes mellitus. Energy and macronutrient intakes of diabetic patients have not been previously studied in this population. We aimed to clarify the energy and nutrient ... -
Azithromycin for Acute Exacerbations of Asthma : The AZALEA Randomized Clinical Trial.
(2016-11)Importance: Guidelines recommend against antibiotic use to treat asthma attacks. A study with telithromycin reported benefit, but adverse reactions limit its use.Objective: To determine whether azithromycin added to standard ... -
Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis.
(2012-10-20)Summary: Objective: To systematically review the use of Quantitative sensory testing (QST) in pain characterisation (phenotyping) in Osteoarthritis (OA). Methods: Six bibliographic databases (Medline, Embase, Amed, Cinahl, ... -
A cross-sectional study of pain sensitivity, disease-activity assessment, mental health, and fibromyalgia status in rheumatoid arthritis.
(2015-01-20)INTRODUCTION: Pain remains the most important problem for people with rheumatoid arthritis (RA). Active inflammatory disease contributes to pain, but pain due to non-inflammatory mechanisms can confound the assessment ... -
Pain sensitivity in healthy volunteers and people with knee Osteoarthritis
(2012)Background: Osteoarthritis (OA) is the most common form of arthritis worldwide and a major cause of pain and disability, and yet underlying mechanisms of OA pain are not entirely understood. There is compelling evidence ... -
Non Invasive Ventilation: Case Study
(British Thoracic Society, 2019-02-18)The Acute Non-Invasive Ventilation (NIV) team at King's Mill Hospital have been asked to collaborate with the British Thoracic Society (BTS) on a case study to share the results of our quality improvement transformation ... -
Ballooned Intercostal Drain Trial
(2017)This study is designed to assess whether a new type of chest drain reduces the number of drains that fall out of or are accidentally removed from the chest cavity (usually requiring another drain to be inserted), without ... -
Can Rheumatologists Predict Eventual Need for Orthopaedic Intervention in Patients with Rheumatoid Arthritis? Results of a Systematic Review and Analysis of Two UK Inception Cohorts.
(2017-03)Purpose of Review: The structural damage caused by rheumatoid arthritis (RA) can often be mitigated by orthopaedic surgery in late disease. This study evaluates the value of predictive factors for orthopaedic interventio ... -
Safety of Nonsteroidal Anti-inflammatory Drugs in Major Gastrointestinal Surgery: A Prospective, Multicenter Cohort Study.
(2017-01)Background: Significant safety concerns remain surrounding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) following gastrointestinal surgery, leading to wide variation in their use. This study aimed to determine ...
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