Browsing Medicine Division by Title
Now showing items 90-109 of 110
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Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis.
(2012-10-20)Summary: Objective: To systematically review the use of Quantitative sensory testing (QST) in pain characterisation (phenotyping) in Osteoarthritis (OA). Methods: Six bibliographic databases (Medline, Embase, Amed, Cinahl, ... -
A Randomized, Open-label, Presurgical, Window-of-Opportunity Study Comparing the Pharmacodynamic Effects of the Novel Oral SERD AZD9496 with Fulvestrant in Patients with Newly Diagnosed ER+ HER2- Primary Breast Cancer.
(2020-08)Purpose: Fulvestrant, the first-in-class selective estrogen receptor (ER) degrader (SERD), is clinically effective in patients with ER+ breast cancer, but it has administration and pharmacokinetic limitations. Pharmacodynamic ... -
Reflections on integrated care from those working in and leading integrated respiratory teams.
(2018-01)The concept of integrated care has been advocated for many years to address some of the challenges faced by the NHS. This report examines the experiences of respiratory healthcare specialists working in an integrated role. ... -
Regional variations in UK colorectal cancer screening and mortality.
(2018-07)The article reports on the regional variations of colorectal cancer screening and mortality in Great Britain. Topics mention including the National Bowel Cancer Screening Programme (NBCSP), reduction of colorectal cancer ... -
Rising HbA1c in the presence of optimal glycaemic control as assessed by self-monitoring - iron deficiency anaemia.
(2016-02)HbA1c can be affected by determinants other than glucose and an awareness of this is important to avoid unnecessary hypoglycaemia. -
Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles.
(2013-05)Summary Background Dose intensification with a combination of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) every 2 weeks improves outcomes in patients older than 60 years with diffuse large B-cell ... -
Safety of Nonsteroidal Anti-inflammatory Drugs in Major Gastrointestinal Surgery: A Prospective, Multicenter Cohort Study.
(2017-01)Background: Significant safety concerns remain surrounding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) following gastrointestinal surgery, leading to wide variation in their use. This study aimed to determine ... -
Shared genetic etiology of obesity-related traits and Barrett's esophagus/adenocarcinoma: Insights from genome-wide association studies.
(2020-02)Background: Obesity is a major risk factor for esophageal adenocarcinoma (EA) and its precursor Barrett's esophagus (BE). Research suggests that individuals with high genetic risk to obesity have a higher BE/EA risk. To ... -
Structural associations of symptomatic knee osteoarthritis.
(2014-11)Objective: Structural changes of osteoarthritis (OA) may occur in the absence of pain. In this study, we aimed to identify histopathologic features that are associated with symptomatic knee OA. Methods: Medial tibial ... -
Surgical lung biopsy for interstitial lung disease: when considered necessary, should these be done in larger and experienced centres only?
(2019-02-21)Surgical lung biopsy for ILD: higher volume centres may offer lower mortality, but data are only suggestive – we need more research, including into lower risk alternatives to conventional biopsy, to reduce risk for patients ... -
Timing of radiotherapy after radical prostatectomy (RADICALS-RT): a randomised, controlled phase 3 trial.
(2020-09-28)Background: The optimal timing of radiotherapy after radical prostatectomy for prostate cancer is uncertain. We aimed to compare the efficacy and safety of adjuvant radiotherapy versus an observation policy with salvage ... -
Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT
(2020-04)Background: Late-stage medial compartment knee osteoarthritis can be treated using total knee replacement or partial (unicompartmental) knee replacement. There is high variation in treatment choice and insufficient evidence ... -
Traits associated with central pain augmentation in the Knee Pain In the Community (KPIC) cohort.
(2018-06)This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n = 420) in the Knee Pain and related health In the Community (KPIC) baseline survey ... -
Trajectories of pain predict disabilities affecting daily living in arthritis.
(2019-04-07)PURPOSE: To examine the interplay between pain and disability in arthritis when adjusting for patient heterogeneity in pain progression. There is consistent evidence to suggest that people experience osteoarthritis ... -
Treatment of tobacco dependence in UK hospitals: an observational study.
(2018-02)Over a million smokers are admitted to hospitals in the UK each year. The extent to which tobacco dependence is identified and addressed in this population is unclear. Data on 14,750 patients from 146 hospitals collected ... -
The UK Pleural Society.
(2019-04)With over 65 separate conditions affecting the pleura it is clear that pleural disease contributes hugely to the workload of respiratory physicians, who increasingly recognize pleural disease as a sub-specialty in its own ... -
Understanding primary parotid squamous cell carcinoma - A systematic review.
(2020-02)Introduction The true incidence of primary parotid squamous cell carcinoma (SCC) is unknown and likely overestimated in the literature. The aim of this systematic review is to examine the diagnosis, aetiology and incidence ... -
Vitamin D and skeletal muscle strength and endurance in COPD.
(2013-02)Jackson, A, Shrikrishna, D, Kelly, J, Kemp, S, Hart, N, Moxham, J, Polkey, M, Kemp, P, & Hopkinson, N 2013, 'Vitamin D and skeletal muscle strength and endurance in COPD', The European Respiratory Journal, 41, 2, pp. 309-316. -
Who Should Be Investigated for Haematuria? Results of a Contemporary Prospective Observational Study of 3556 Patients
(2018-03-07)Abstract: There remains a lack of consensus among guideline relating to which patients require investigation for haematuria. We determined the incidence of urinary tract cancer in a prospective observational study of ...
