Browsing Medicine Division by Title
Now showing items 1-20 of 110
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6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE): 4-year disease-free survival results of a randomised phase 3 non-inferiority trial.
(2019-06-06)BACKGROUND: Adjuvant trastuzumab significantly improves outcomes for patients with HER2-positive early breast cancer. The standard treatment duration is 12 months but shorter treatment could provide similar efficacy while ... -
Acidophil stem cell pituitary adenoma: a case report and literature review.
(2019-12)In this article, we describe a very rare case of pituitary acidophilic stem cell adenoma, accompanied by a literature review. We present the case of 33-year-old woman with a history of amenorrhea, galactorrhea, elevated ... -
Acute presentation of a partially obstructing laryngeal tumour: adjuvant agents to gaseous induction of anaesthesia.
(2018-07)We present the case of a 53-year-old man who attended our emergency department with stridor. He had recently undergone investigation for possible glottic cancer. We discuss the airway management of such a case. We believe ... -
Acute Transient Stress Induced Adrenal Hypertrophy and Adrenal Medullary Hyperactivity.
(2015)Objectives: Adrenal gland hypertrophy can be related to acute stress with abnormal adrenal function tests. It may not always need treatment. Material and methods: An acute presentation of adrenal gland hypertrophy following ... -
Association between rheumatoid arthritis disease activity, progression of functional limitation and long-term risk of orthopaedic surgery: Combined analysis of two prospective cohorts supports EULAR treat to target DAS thresholds.
(2016-12)bjectives: To examine the association between disease activity in early rheumatoid arthritis (RA), functional limitation and long-term orthopaedic episodes. Methods: Health Assessment Questionnaire (HAQ) disability scores ... -
Association of FTO and near MC4R variants with obesity measures in urban and rural dwelling Sri Lankans
(2016-09)Objectives: To investigate the association between the fat mass and obesity related (FTO) gene rs9939609 and near melanocortin-4-receptor (MC4R) gene rs17782313 polymorphisms with obesity measures and metabolic parameters ... -
Association of the leptin receptor Q223R (rs1137101) polymorphism with obesity measures in Sri Lankans.
(2020-01-16)Objective: The role of genetic factors in the development of obesity is largely unreported in Sri Lankans. The Q223R (rs1137101) single nucleotide polymorphism (SNP) of the leptin receptor (LEPR) gene has been associated ... -
Associations of symptomatic knee Osteoarthritis with histopathologic features in subchondral bone.
(2019-01-21)OBJECTIVES: Subchondral bone and the osteochondral junction are thought to contribute to osteoarthritis (OA) knee pain. We aimed to identify osteochondral pathologies specifically associated with symptomatic human knee OA. ... -
Azithromycin for Acute Exacerbations of Asthma : The AZALEA Randomized Clinical Trial.
(2016-11)Importance: Guidelines recommend against antibiotic use to treat asthma attacks. A study with telithromycin reported benefit, but adverse reactions limit its use.Objective: To determine whether azithromycin added to standard ... -
Ballooned Intercostal Drain Trial
(2017)This study is designed to assess whether a new type of chest drain reduces the number of drains that fall out of or are accidentally removed from the chest cavity (usually requiring another drain to be inserted), without ... -
Baseline factors predicting change from the initial DMARD treatment during the first 2 years of rheumatoid arthritis: experience in the ERAN inception cohort
(2013-05)BACKGROUND: Outcomes in early Rheumatoid Arthritis (RA) may be improved by rapidly establishing a stable and effective disease modifying anti-rheumatic drug (DMARD) treatment regimen. We aimed to investigate whether baseline ... -
Baseline self-report 'central mechanisms' trait predicts persistent knee pain in the Knee Pain in the Community (KPIC) cohort
(2019-12)Objectives: We investigated whether baseline scores for a self-report trait linked to central mechanisms predict 1 year pain outcomes in the Knee Pain in the Community cohort. Method: 1471 participants reported knee pain ... -
Breathlessness in an ex-miner: an unusual consideration.
(2016-05)The article presents a case study of a 73-year-old retired miner, with 36 years at the coal face, who was presented with a 5-year history of exertional dyspnoea on climbing steep inclines. His medical history was limited ... -
Bronchoscopic intrabullous autologous blood instillation: a novel approach for the treatment of giant bullae.
(2013-10)The current standard therapy for patients with giant bullae is surgical bullectomy; however, high operative risk and comorbidities preclude surgical procedures in many patients. Autologous blood instilled directly into ... -
Can Rheumatologists Predict Eventual Need for Orthopaedic Intervention in Patients with Rheumatoid Arthritis? Results of a Systematic Review and Analysis of Two UK Inception Cohorts.
(2017-03)Purpose of Review: The structural damage caused by rheumatoid arthritis (RA) can often be mitigated by orthopaedic surgery in late disease. This study evaluates the value of predictive factors for orthopaedic interventio ... -
Chronic obstructive pulmonary disease: diagnosis and management: summary of updated NICE guidance.
(2019-07-29)This article summarises the most recent recommendations from the National Institute for Health and Care Excellence (NICE). The updated areas are mainly concerned with the management of stable COPD and include self management ... -
Clinical course of a 66-year-old man with an acute ischaemic stroke in the setting of a COVID-19 infection.
(2020-08)A 66-year-old man was admitted to hospital with a right frontal cerebral infarct producing left-sided weakness and a deterioration in his speech pattern. The cerebral infarct was confirmed with CT imaging. The only evidence ... -
Clinically important associations of pleurodesis success in malignant pleural effusion: Analysis of the TIME1 data set.
(2020-07)Background and Objective: Chemical pleurodesis is performed for patients with MPE with a published success rate of around 80%. It has been postulated that inflammation is key in achieving successful pleural symphysis, as ...
