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Association of the leptin receptor Q223R (rs1137101) polymorphism with obesity measures in Sri Lankans.
(2020-01-16)
Objective: The role of genetic factors in the development of obesity is largely unreported in Sri Lankans. The Q223R (rs1137101) single nucleotide polymorphism (SNP) of the leptin receptor (LEPR) gene has been associated ...
Experiences of using vedolizumab in the treatment of inflammatory bowel disease in the East Midlands UK - a retrospective observational study.
(2020-07-11)
Purpose: Clinical trials have demonstrated efficacy of vedolizumab in ulcerative colitis (UC) and Crohn's disease (CD). Further real-world data is needed to inform clinical practice. The primary outcome was to assess ...
Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats.
(2020-05)
Summary Objectives: Subchondral bone may contribute to knee osteoarthritis (OA) pain. Nerve growth factor (NGF) can stimulate nerve growth through TrkA. We aimed to identify how sensory nerve growth at the osteochondral ...
Investigating musculoskeletal health and wellbeing; a cohort study protocol.
(2020-03)
Background: In an ageing population, pain, frailty and disability frequently coexist across a wide range of musculoskeletal diagnoses, but their associations remain incompletely understood. The Investigating Musculoskeletal ...
Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT
(2020-04)
Background: Late-stage medial compartment knee osteoarthritis can be treated using total knee replacement or partial (unicompartmental) knee replacement. There is high variation in treatment choice and insufficient evidence ...