Rheumatology
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Measure of activity performance of the hand (MAP-Hand) questionnaire: linguistic validation, cultural adaptation and psychometric testing in people with rheumatoid arthritis in the UK
(2018-07-31)BACKGROUND: Developed in the Norway, the Measure of Activity Performance of the Hand (MAP-Hand) assesses 18 activities performed using the hands. It was developed for people with rheumatoid arthritis (RA) using patient ... -
Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis.
(2019-04)OBJECTIVE: Osteoarthritis (OA) is a major source of knee pain. Mechanisms of OA knee pain are incompletely understood but include synovial pathology. We aimed to identify molecular expression patterns in the synovium ... -
The impact of anxiety on chronic musculoskeletal pain and the role of astrocyte activation.
(2019-03)Anxiety and depression are associated with increased pain responses in chronic pain states. The extent to which anxiety drives chronic pain, or vice versa, remains an important question that has implications for analgesic ... -
The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis.
(2019-03-18)Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. Identification of the mechanisms driving inflammation could reveal new targets to relieve this prevalent pain state. Herein, a ... -
Trajectories of pain predict disabilities affecting daily living in arthritis.
(2019-04-07)PURPOSE: To examine the interplay between pain and disability in arthritis when adjusting for patient heterogeneity in pain progression. There is consistent evidence to suggest that people experience osteoarthritis ... -
Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data.
(McWilliams, D. F. et al. (2016) ‘Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data’, Arthritis Research & Therapy, 18, p. 295., 2016-12-13)ACKGROUND: Rheumatoid arthritis (RA) disease activity is often measured using the 28-joint Disease Activity Score (DAS28). We aimed to identify and independently verify subgroups of people with RA that may be discordant ... -
Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis.
(2012-10-20)Summary: Objective: To systematically review the use of Quantitative sensory testing (QST) in pain characterisation (phenotyping) in Osteoarthritis (OA). Methods: Six bibliographic databases (Medline, Embase, Amed, Cinahl, ... -
A cross-sectional study of pain sensitivity, disease-activity assessment, mental health, and fibromyalgia status in rheumatoid arthritis.
(2015-01-20)INTRODUCTION: Pain remains the most important problem for people with rheumatoid arthritis (RA). Active inflammatory disease contributes to pain, but pain due to non-inflammatory mechanisms can confound the assessment ... -
Pain sensitivity in healthy volunteers and people with knee Osteoarthritis
(2012)Background: Osteoarthritis (OA) is the most common form of arthritis worldwide and a major cause of pain and disability, and yet underlying mechanisms of OA pain are not entirely understood. There is compelling evidence ... -
Can Rheumatologists Predict Eventual Need for Orthopaedic Intervention in Patients with Rheumatoid Arthritis? Results of a Systematic Review and Analysis of Two UK Inception Cohorts.
(2017-03)Purpose of Review: The structural damage caused by rheumatoid arthritis (RA) can often be mitigated by orthopaedic surgery in late disease. This study evaluates the value of predictive factors for orthopaedic interventio ... -
Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis.
(2018-12)Objective: Osteoarthritis (OA) is a major source of knee pain. Mechanisms of OA knee pain are incompletely understood but include synovial pathology. We aimed to identify molecular expression patterns in the synovium ... -
Discrete Trajectories of Resolving and Persistent Pain in People With Rheumatoid Arthritis Despite Undergoing Treatment for Inflammation: Results From Three UK Cohorts.
(2019-01-15)Rheumatoid arthritis (RA) is an example of human chronic inflammatory pain. Modern treatments suppress inflammation, yet pain remains a major problem for many people with RA. We hypothesized that discrete RA subgroups might ... -
Associations of symptomatic knee Osteoarthritis with histopathologic features in subchondral bone.
(2019-01-21)OBJECTIVES: Subchondral bone and the osteochondral junction are thought to contribute to osteoarthritis (OA) knee pain. We aimed to identify osteochondral pathologies specifically associated with symptomatic human knee OA. ... -
Interpretation of 28-Joint Disease Activity Score and its Components in the Assessment of Inflammatory and Non-Inflammatory Aspects of Rheumatoid Arthritis
(2016-04-28)Background: The 28-joint DAS with ESR (DAS28-ESR) is used as a measure of inflammatory disease activity in RA. However, pain and non-inflammatory mechanisms (e.g. central sensitisation) might confound the DAS28 by modulating ... -
Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomized controlled trial.
(2018-02)Objective: To determine the feasibility of conducting a trial of a pre-surgical psychological intervention on pain, function, and mood in people with knee osteoarthritis listed for total knee arthroplasty. Design: ... -
Home-administered pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): study protocol for a randomised controlled trial.
(2016-01-27)Background: Knee replacement surgery reduces pain for many people with osteoarthritis (OA). However, surgical outcomes are partly dependent on patients' moods, and those with depression or anxiety have worse outcomes. ... -
Work disability and state benefit claims in early rheumatoid arthritis: the ERAN cohort.
(2014-03)Objective: RA is an important cause of work disability. This study aimed to identify predictive factors for work disability and state benefit claims in a cohort with early RA. Methods: The Early RA Network (ERAN) inception ... -
Structural associations of symptomatic knee osteoarthritis.
(2014-11)Objective: Structural changes of osteoarthritis (OA) may occur in the absence of pain. In this study, we aimed to identify histopathologic features that are associated with symptomatic knee OA. Methods: Medial tibial ... -
Predicting responses in patients with rheumatoid arthritis to disease-modifying agents using baseline clinical data
(2017-09)Objectives: The optimal treatment for active rheumatoid arthritis (RA) is unresolved, particularly in early RA. We used data from an observational cohort to develop the simple predictor algorithm and evaluated its application ... -
Histopathological subgroups in knee osteoarthritis
(2017-01)OBJECTIVE: Osteoarthritis (OA) is a heterogeneous, multi-tissue disease. We hypothesised that different histopathological features characterise different stages during knee OA progression, and that discrete subgroups can ...
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