Rheumatology
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Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats.
(2020-09)Summary Objectives Subchondral bone may contribute to knee osteoarthritis (OA) pain. Nerve growth factor (NGF) can stimulate nerve growth through TrkA. We aimed to identify how sensory nerve growth at the osteochondral ... -
Investigating musculoskeletal health and wellbeing; a cohort study protocol.
(2020-03)Background: In an ageing population, pain, frailty and disability frequently coexist across a wide range of musculoskeletal diagnoses, but their associations remain incompletely understood. The Investigating Musculoskeletal ... -
Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT
(2020-04)Background: Late-stage medial compartment knee osteoarthritis can be treated using total knee replacement or partial (unicompartmental) knee replacement. There is high variation in treatment choice and insufficient evidence ... -
Disease activity flares and pain flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae.
(2019-11)Background: RA flares are common and disabling. They are described in terms of worsening inflammation but pain and inflammation are often discordant. To inform treatment decisions, we investigated whether inflammatory and ... -
Quantitative sensory testing and predicting outcomes for musculoskeletal pain, disability, and negative affect: a systematic review and meta-analysis.
(2019-09)Hypersensitivity due to central pain mechanisms can influence recovery and lead to worse clinical outcomes, but the ability of quantitative sensory testing (QST), an index of sensitisation, to predict outcomes in chronic ... -
Baseline self-report 'central mechanisms' trait predicts persistent knee pain in the Knee Pain in the Community (KPIC) cohort
(2019-12)Objectives: We investigated whether baseline scores for a self-report trait linked to central mechanisms predict 1 year pain outcomes in the Knee Pain in the Community cohort. Method: 1471 participants reported knee pain ... -
Traits associated with central pain augmentation in the Knee Pain In the Community (KPIC) cohort.
(2018-06)This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n = 420) in the Knee Pain and related health In the Community (KPIC) baseline survey ... -
Measure of activity performance of the hand (MAP-Hand) questionnaire: linguistic validation, cultural adaptation and psychometric testing in people with rheumatoid arthritis in the UK
(2018-07-31)BACKGROUND: Developed in the Norway, the Measure of Activity Performance of the Hand (MAP-Hand) assesses 18 activities performed using the hands. It was developed for people with rheumatoid arthritis (RA) using patient ... -
Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis.
(2019-04)OBJECTIVE: Osteoarthritis (OA) is a major source of knee pain. Mechanisms of OA knee pain are incompletely understood but include synovial pathology. We aimed to identify molecular expression patterns in the synovium ... -
The impact of anxiety on chronic musculoskeletal pain and the role of astrocyte activation.
(2019-03)Anxiety and depression are associated with increased pain responses in chronic pain states. The extent to which anxiety drives chronic pain, or vice versa, remains an important question that has implications for analgesic ... -
The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis.
(2019-03-18)Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. Identification of the mechanisms driving inflammation could reveal new targets to relieve this prevalent pain state. Herein, a ... -
Trajectories of pain predict disabilities affecting daily living in arthritis.
(2019-04-07)PURPOSE: To examine the interplay between pain and disability in arthritis when adjusting for patient heterogeneity in pain progression. There is consistent evidence to suggest that people experience osteoarthritis ... -
Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data.
(McWilliams, D. F. et al. (2016) ‘Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data’, Arthritis Research & Therapy, 18, p. 295., 2016-12-13)ACKGROUND: Rheumatoid arthritis (RA) disease activity is often measured using the 28-joint Disease Activity Score (DAS28). We aimed to identify and independently verify subgroups of people with RA that may be discordant ... -
Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis.
(2012-10-20)Summary: Objective: To systematically review the use of Quantitative sensory testing (QST) in pain characterisation (phenotyping) in Osteoarthritis (OA). Methods: Six bibliographic databases (Medline, Embase, Amed, Cinahl, ... -
A cross-sectional study of pain sensitivity, disease-activity assessment, mental health, and fibromyalgia status in rheumatoid arthritis.
(2015-01-20)INTRODUCTION: Pain remains the most important problem for people with rheumatoid arthritis (RA). Active inflammatory disease contributes to pain, but pain due to non-inflammatory mechanisms can confound the assessment ... -
Pain sensitivity in healthy volunteers and people with knee Osteoarthritis
(2012)Background: Osteoarthritis (OA) is the most common form of arthritis worldwide and a major cause of pain and disability, and yet underlying mechanisms of OA pain are not entirely understood. There is compelling evidence ... -
Can Rheumatologists Predict Eventual Need for Orthopaedic Intervention in Patients with Rheumatoid Arthritis? Results of a Systematic Review and Analysis of Two UK Inception Cohorts.
(2017-03)Purpose of Review: The structural damage caused by rheumatoid arthritis (RA) can often be mitigated by orthopaedic surgery in late disease. This study evaluates the value of predictive factors for orthopaedic interventio ... -
Discrete Trajectories of Resolving and Persistent Pain in People With Rheumatoid Arthritis Despite Undergoing Treatment for Inflammation: Results From Three UK Cohorts.
(2019-01-15)Rheumatoid arthritis (RA) is an example of human chronic inflammatory pain. Modern treatments suppress inflammation, yet pain remains a major problem for many people with RA. We hypothesized that discrete RA subgroups might ... -
Associations of symptomatic knee Osteoarthritis with histopathologic features in subchondral bone.
(2019-01-21)OBJECTIVES: Subchondral bone and the osteochondral junction are thought to contribute to osteoarthritis (OA) knee pain. We aimed to identify osteochondral pathologies specifically associated with symptomatic human knee OA. ... -
Interpretation of 28-Joint Disease Activity Score and its Components in the Assessment of Inflammatory and Non-Inflammatory Aspects of Rheumatoid Arthritis
(2016-04-28)Background: The 28-joint DAS with ESR (DAS28-ESR) is used as a measure of inflammatory disease activity in RA. However, pain and non-inflammatory mechanisms (e.g. central sensitisation) might confound the DAS28 by modulating ...
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