Now showing items 1-6 of 6
Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomized controlled trial.
Objective: To determine the feasibility of conducting a trial of a pre-surgical psychological intervention on pain, function, and mood in people with knee osteoarthritis listed for total knee arthroplasty. Design: ...
Home-administered pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): study protocol for a randomised controlled trial.
Background: Knee replacement surgery reduces pain for many people with osteoarthritis (OA). However, surgical outcomes are partly dependent on patients' moods, and those with depression or anxiety have worse outcomes. ...
Associations of symptomatic knee Osteoarthritis with histopathologic features in subchondral bone.
OBJECTIVES: Subchondral bone and the osteochondral junction are thought to contribute to osteoarthritis (OA) knee pain. We aimed to identify osteochondral pathologies specifically associated with symptomatic human knee OA. ...
Investigating musculoskeletal health and wellbeing; a cohort study protocol.
Background: In an ageing population, pain, frailty and disability frequently coexist across a wide range of musculoskeletal diagnoses, but their associations remain incompletely understood. The Investigating Musculoskeletal ...
Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT
Background: Late-stage medial compartment knee osteoarthritis can be treated using total knee replacement or partial (unicompartmental) knee replacement. There is high variation in treatment choice and insufficient evidence ...
Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats.
Summary Objectives: Subchondral bone may contribute to knee osteoarthritis (OA) pain. Nerve growth factor (NGF) can stimulate nerve growth through TrkA. We aimed to identify how sensory nerve growth at the osteochondral ...