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dc.contributor.authorPersic, Mojca
dc.date.accessioned2016-08-24T12:47:39Z
dc.date.available2016-08-24T12:47:39Z
dc.date.issued2016-02
dc.identifier.citationJ Cutan Pathol. 2016 Feb;43(2):125-36. doi: 10.1111/cup.12633. Epub 2015 Nov 13.language
dc.identifier.urihttps://orda.derbyhospitals.nhs.uk/handle/123456789/189
dc.descriptionAuthor(s) Pre Print Onlylanguage
dc.description.abstractBACKGROUND: Primary cutaneous indolent CD8-positive lymphoid proliferation is an emerging entity characterized by slowly enlarging papules and nodules that are pathologically comprised of clonal nonepidermotropic medium-sized atypical CD8(+) T-cells. Although the majority of lesions are solitary and located on the ears,v bilateral symmetrical presentations have been described and lesions may arise at other peripheral or 'acral' sites. Patients follow a benign clinical course and systemic involvement has not yet been observed. Despite this, some medical practitioners classify such lesions as peripheral T-cell lymphoma, NOS, a category implying aggressive disease. OBJECTIVES: We present three cases seen in our institutions and provide an update on a previously reported unique patient who continues to develop recurrent and multifocal skin lesions. RESULTS: Systemic disease progression has not been observed, even in the presence of recurrent and multifocal cutaneous disease. CONCLUSIONS: Indolent CD8-positive lymphoid proliferation of acral sites is a distinctive and readily identifiable entity and should be included in the next consensus revision of cutaneous lymphoma classification. Although cases described thus far have followed an indolent clinical course, dermatologists should remain guarded about the prognosis and full staging and longitudinal observation are recommended until this condition is better understoodlanguage
dc.language.isoenlanguage
dc.subjectCD8language
dc.subjectAcrallanguage
dc.subjectIndolentlanguage
dc.subjectLymphoid Proliferationlanguage
dc.subjectLymphomalanguage
dc.titleIndolent CD8-positive lymphoid proliferation of acral sites: three further cases of a rare entity and an update on a unique patient.language
dc.typeArticlelanguage


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