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dc.contributor.authorChorley, W
dc.date.accessioned2020-07-15T12:17:56Z
dc.date.available2020-07-15T12:17:56Z
dc.date.issued2020-06
dc.identifier.citationFam Cancer. 2020 Jun 11. doi: 10.1007/s10689-020-00188-z. [Epub ahead of print]en
dc.identifier.urihttps://orda.derbyhospitals.nhs.uk/handle/123456789/2228
dc.descriptionAuthor(s) Pre or Post-Print Version Onlyen
dc.description.abstractFamily history of breast cancer is a key risk factor, accounting for up to 10% of cancers. We evaluated the proactive assessment of familial breast cancer (FBC) risk in primary care. Eligible women (30 to 60 years) were recruited from eight English general practices. Practices were trained on FBC risk assessment. In four randomly-assigned practices, women were invited to complete a validated, postal family history questionnaire, which practice staff inputted into decision support software to determine cancer risk. Those with increased risk were offered specialist referral. Usual care was observed in the other four practices. In intervention practices, 1127/7012 women (16.1%) returned family history questionnaires, comprising 1105 (98%) self-reported white ethnicity and 446 (39.6%) educated to University undergraduate or equivalent qualification, with 119 (10.6%) identified at increased breast cancer risk and offered referral. Sixty-seven (56%) women recommended referral were less than 50 years old. From 66 women attending specialists, 26 (39.4%) were confirmed to have high risk and recommended annual surveillance (40-60 years) and surgical prevention; while 30 (45.5%) were confirmed at moderate risk, with 19 offered annual surveillance (40-50 years). The remaining 10 (15.2%) managed in primary care. None were recommended chemoprevention. In usual care practices, only ten women consulted with concerns about breast cancer family history. This study demonstrated proactive risk assessment in primary care enables accurate identification of women, including many younger women, at increased risk of breast cancer. To improve generalisability across the population, more active methods of engagement need to be explored.Trial registration: CRUK Clinical Trials Database 11779.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectDecision Supporten
dc.subjectFamily Historyen
dc.subjectMedical Geneticsen
dc.subjectPrimary Health Careen
dc.subjectRisk Assessmenten
dc.titleImproving primary care identification of familial breast cancer risk using proactive invitation and decision support.en
dc.typeArticleen


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