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dc.contributor.authorWalsh, David A.
dc.date.accessioned2020-07-28T16:58:56Z
dc.date.available2020-07-28T16:58:56Z
dc.date.issued2020-03
dc.identifier.citationMillar, B. et al. (2020) ‘Investigating musculoskeletal health and wellbeing; a cohort study protocol’, BMC musculoskeletal disorders, 21(1), p. 182. doi: 10.1186/s12891-020-03195-4.en
dc.identifier.otherPMCID: PMC7085148
dc.identifier.otherDOI: 10.1186/s12891-020-03195-4
dc.identifier.urihttps://orda.derbyhospitals.nhs.uk/handle/123456789/2288
dc.descriptionOpen Access: This article is licensed under a Creative Commons Attribution 4.0 International License.en
dc.description.abstractBackground: In an ageing population, pain, frailty and disability frequently coexist across a wide range of musculoskeletal diagnoses, but their associations remain incompletely understood. The Investigating Musculoskeletal Health and Wellbeing (IMH&W) study aims to measure and characterise the development and progression of pain, frailty and disability, and to identify discrete subgroups and their associations. The survey will form a longitudinal context for nested research, permitting targeted recruitment of participants for qualitative, observational and interventional studies; helping to understand recruitment bias in clinical studies; and providing a source cohort for cohort randomised controlled trials. Methods: IMH&W will comprise a prospective cohort of 10,000 adults recruited through primary and secondary care, and through non-clinical settings. Data collection will be at baseline, and then through annual follow-ups for 4 years. Questionnaires will address demographic characteristics, pain severity (0-10 Numerical Rating Scale), pain distribution (reported on a body Manikin), pain quality (McGill Pain Questionnaire), central aspects of pain (CAP-Knee), frailty and disability (based on Fried criteria and the FRAIL questionnaire), and fracture risk. Baseline characteristics, progression and associations of frailty, pain and disability will be determined. Discrete subgroups and trajectories will be sought by latent class analysis. Recruitment bias will be explored by comparing participants in nested studies with the eligible IMH&W population. Discussion: IMH&W will elucidate associations and progression of pain, frailty and disability. It will enable identification of people at risk of poor musculoskeletal health and wellbeing outcomes who might be suitable for specific interventions, and facilitate generalisation and comparison of research outcomes between target populations. The study will benefit from a large sample size and will recruit from diverse regions across the UK. Purposive recruitment will enrich the cohort with people with MSK problems with high representation of elderly and unwell people.en
dc.description.sponsorshipNottingham Biomedical Research Centre National Institute for Health Research; 20777 United Kingdom VAC_ Versus Arthritisen
dc.language.isoenen
dc.subjectKnee Osteoarthritisen
dc.subjectPainen
dc.subjectFrailtyen
dc.titleInvestigating musculoskeletal health and wellbeing; a cohort study protocol.en
dc.typeArticleen


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