Browsing Dementia by Author "Heun, Reinhard"
Now showing items 1-15 of 15
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A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk.
(2013)We assessed the role of rare copy number variants (CNVs) in Alzheimer's disease (AD) using intensity data from 3260 AD cases and 1290 age-matched controls from the genome-wide association study (GWAS) conducted by the ... -
Alzheimer's disease and co-morbidity: Increased prevalence and possible risk factors of excess mortality in a naturalistic 7-year follow-up
(2013)Background. - Subjects with late-onset Alzheimer's disease (AD) have to be sufficiently healthy to live long enough to experience and to be diagnosed with dementia in later life. In contrast, neurodegeneration and cognitive ... -
Blood type gene locus has no influence on ACE association with Alzheimer's disease
(2015)The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (. ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only ... -
Co-morbidity and mortality in alzheimer's disease.
(2015)Introduction. The interface of physical and mental health and its relevance for diagnosis and therapy in Alzheimer's disease (AD) is clinically relevant for efforts that aim on the reduction of avoidable mortality. Objectives ... -
Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease.
(2013)Despite recent discoveries in the genetics of sporadic Alzheimer's disease, there remains substantial "hidden heritability." It is thought that some of this missing heritability may be because of gene-gene, i.e., epistatic, ... -
Estimation and partitioning of polygenic variation captured by common snps for alzheimer's disease, multiple sclerosis and endometriosis.
(2013)Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple sclerosis (MS) account for a significant proportion of the health care burden in many countries. Genome-wide association studies (GWASs) for ... -
Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis
(2014)Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking cholesterol ... -
Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology
(2013)GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds ratios (ORs) ranging from 0.75-0.85. We tested eight GAB2 variants ... -
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Role of PLD3 rare variants in european non-familial Alzheimer's disease
(2015)Interest in the role of rare genetic variants in the etiology of complex diseases such as Alzheimer's disease (AD) is increasing. In January 2014, Cruchaga et al. provided evidence supporting the role of rare variants in ... -
Role of PLD3 rare variants in european sporadic Alzheimer's disease patients.
(2014)Background: Alzheimer's disease (AD) is a severe multifactorial disorder and the individual genetic predisposition plays a decisive role in its etiology. While genome-wide association studies have been successful in ... -
Screening exons 16 and 17 of the amyloid precursor protein gene in sporadic early-onset Alzheimer's disease
(2016)Early-onset Alzheimer's disease (EOAD) can be familial (FAD) or sporadic EOAD (sEOAD); both have a disease onset <65 years of age. A total of 451 sEOAD samples were screened for known causative mutations in exons 16 and ... -
The efficacy of agomelatine in elderly patients with recurrent major depressive disorder: A placebo-controlled study
(2013)Objective: The present placebo-controlled study evaluated the efficacy, tolerability, and safety of 8-week treatment with agomelatine (25-50 mg/d by mouth) in elderly patients with major depressive disorder (MDD). Method: ... -
The sex-specific associations of the aromatase gene with Alzheimer's disease and its interaction with IL10 in the Epistasis Project
(2014)Epistasis between interleukin-10 (IL10) and aromatase gene polymorphisms has previously been reported to modify the risk of Alzheimer's disease (AD). However, although the main effects of aromatase variants suggest a ... -
TREM2 variants in Alzheimer's disease
(2013)Background: Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia. ...
