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dc.contributor.authorOdudu, Aghogho
dc.contributor.authorLambie, Stewart
dc.contributor.authorTaal, Maarten
dc.contributor.authorFluck, Richard
dc.contributor.authorMcIntyre, Christopher
dc.date.accessioned2016-10-25T15:12:20Z
dc.date.available2016-10-25T15:12:20Z
dc.date.issued2011-07
dc.identifier.citationKidney Blood Press Res. 2011;34(6):439-46. doi: 10.1159/000329355. Epub 2011 Jul 27.language
dc.identifier.urihttps://orda.derbyhospitals.nhs.uk/handle/123456789/559
dc.description.abstractBACKGROUND: Failure to achieve isonatric haemodialysis (HD) drives an expansion of extracellular volume leading to increased interdialytic weight gain (IDWG). This may be a causative factor in the development of HD-induced cardiac injury. We examined total and diffusive sodium mass balance during HD. METHODS: 24 chronic HD patients using a fixed 140 mmol/l sodium concentration were studied over 4 weeks. Dialysate and plasma conductivity and ionic mass balance (IMB) were recorded. IMB estimates total ionic transfer across the membrane. RESULTS: Mean total IMB was 338 mmol indicating net sodium removal. Intrapatient variability was less than interpatient variability (coefficient of variation = 42 vs. 26%, respectively). The diffusive component of ionic mass balance (IMB(diff)) was 97 ± 18 mmol approximating 29% (±22-36) of total sodium removal. IMB(diff) also correlated with both plasma conductivity and predialysis plasma sodium (r(2) = 0.82 and 0.6, respectively; p < 0.0001) as well as the reduction in plasma conductivity and plasma sodium during HD (r(2) = 0.7 and 0.5, respectively; p < 0.0001). CONCLUSION: HD against a fixed dialysate sodium concentration of 140 mmol/l results in a wide range of sodium removal with a mean of 29% removed by diffusion. Online conductivity monitoring can be utilized as part of a variety of strategies to enable the delivery of individualised and isonatric HD. Further study is required to explore the utility of such strategies which may be crucial in reducing IDWG and HD-induced cardiac injury.language
dc.language.isoenlanguage
dc.subjectOnline Conductivity Monitoringlanguage
dc.subjectSodium Mass Balancelanguage
dc.subjectChronic Haemodialysis Patientslanguage
dc.titleUse of online conductivity monitoring to study sodium mass balance in chronic haemodialysis patients: prospects for treatment individualisation.language
dc.typeArticlelanguage


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