ORDA - Online Research Data Archive 
    • Login
    View Item 
    •   ORDA Home
    • University Hospitals of Derby and Burton NHS Foundation Trust
    • Division of Medicine
    • Specialist Medicine
    • View Item
    •   ORDA Home
    • University Hospitals of Derby and Burton NHS Foundation Trust
    • Division of Medicine
    • Specialist Medicine
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Chronic kidney disease in older people - diagnosis, aetiology and consequences.

    Thumbnail
    Abstract
    PURPOSE OF REVIEW: The prevalence of chronic kidney disease (CKD) steeply rises with age but there is controversy regarding the diagnosis and clinical significance of CKD in older people. This article reviews recent advances in our understanding with respect to the diagnosis, aetiology and adverse outcomes associated with CKD in older people. RECENT FINDINGS: Comparisons with measured glomerular filtration rate in a cohort of older people found that the Chronic Kidney Disease Epidemiology Collaboration equation using creatinine and cystatin C performs at least as well as other equations developed to estimate glomerular filtration rate in older populations. Several studies have identified modifiable risk factors in earlier life that are associated with increased risk of developing CKD in later life, including blood pressure, biomarkers of cardiovascular disease and lower serum bicarbonate. Numerous studies have confirmed that CKD in older people is associated with an increased risk of multiple adverse outcomes including death, end-stage kidney disease, cardiovascular events, acute kidney injury, severe infections and cognitive decline. SUMMARY: CKD is associated with the same adverse outcomes in older people as younger people. Further studies are required to develop interventions to reduce the incidence of CKD in older people and improve the associated adverse outcomes.
    URI
    https://orda.derbyhospitals.nhs.uk/handle/123456789/661
    Collections
    • Specialist Medicine [375]
    Date
    2015-11
    Author
    Taal, Maarten
    Show full item record

    copyright © 2017  Derby Teaching Hospitals NHS Foundation Trust
    Contact Us | Send Feedback
    Powered by KnowledgeArc
     

     

    Browse

    All of ORDACommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    Researcher Profiles

    Researchers

    My Account

    Login

    copyright © 2017  Derby Teaching Hospitals NHS Foundation Trust
    Contact Us | Send Feedback
    Powered by KnowledgeArc